Nature Cell Biology

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  • doi:10.1038/s41556-017-0006-y

    PERK regulates tumour cell survival. Bu et al. show that the unfolded protein response protein PERK induces miR-211 repression of the circadian factor Bmal1 to regulate protein synthesis and stress responses, contributing to tumour progression.' );return false" > A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival
  • doi:10.1038/s41556-017-0002-2

    Glycogen metabolism controls memory T cells. Ma et al. show that the metabolic gene PCK1 promotes glycogen formation, which is used in the pentose phosphate pathway, generating glutathione that is important for counteraction of ROS and thus promotion of memory T-cell maintenance, and resulting in improved antitumour immunity.' );return false" > A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells
  • doi:10.1038/s41556-017-0007-x

    An and Harper quantify ribophagy in mammalian cells and show that nutrient-deprivation-induced ribophagy is independent of the ATG8 conjugation system, whereas proteotoxic stress-induced ribophagy requires ATG5 and VPS34.' );return false" > Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy
  • doi:10.1038/s41556-017-0005-z

    Mechanics of epidermal differentiation Miroshnikova et al. find that during embryonic development, epidermal basal layer crowding generates local changes in cell shape, cortical tension, and adhesion that initiate differentiation and delamination' );return false" > Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification
  • doi:10.1038/s41556-017-0001-3

    Takeda et al. reveal that the shortening of epithelial cells required for dorsal fold initiation in Drosophila embryos is driven by a microtubule-based mechanism involving dynein-mediated forces and Katanin-dependent remodelling.' );return false" > A homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shift
  • doi:10.1038/s41556-017-0003-1

    Dziedzic et al. show that the ubiquitin-binding protein ABIN-1 is recruited into TNFR1 signalling complex in a manner dependent on Met1 -ubiquitinating complex LUBAC to regulate K63 de-ubiquitination to activate RIPK1.' );return false" > ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
  • doi:10.1038/ncb3648

    Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis' );return false" > Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
  • doi:10.1038/ncb3652

    Advances in stem cell research offer unprecedented insights into human biology and opportunities for clinical translation. They also raise many questions with social and ethical implications.' );return false" > Of stem cells and ethics
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