Nature Genetics

Nature Genetics Advance Online Publication

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  • doi:10.1038/s41588-018-0055-6

    The authors find that, in a high-fat diet (HFD) mouse model, levels of Stella protein are reduced in oocytes, leading to abnormal epigenetic patterning during development and to embryonic growth defects. Overexpression of Stella in oocytes from HFD-fed mice partially ameliorates developmental defects.' );return false" > Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes
  • doi:10.1038/s41588-018-0054-7

    A CRISPR-based functional screen for Hedgehog-pathway factors identifies genes required for ciliary signaling and can be used to classify genetic disorders as ciliopathies.' );return false" > A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
  • doi:10.1038/s41588-018-0057-4

    The authors report a data-driven approach to phenotyping 3D facial shape. They apply their methodology to 2,329 individuals of European ancestry and identify 38 loci that associate with specific facial morphologies, some of which overlap with neural-crest-specific regulatory regions.' );return false" > Genome-wide mapping of global-to-local genetic effects on human facial shape
  • doi:10.1038/s41588-018-0061-8

    The authors report that DNA methylation coevolves with the DNA alkylation repair enzyme ALKB2 across eukaryotes. They also show that DNA methyltransferases cause alkylation damage in vitro and in vivo by introducing 3-methylcytosine into DNA.' );return false" > Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity
  • doi:10.1038/s41588-018-0056-5

    Meta-analysis of data from 58,265 cattle shows that the genetic architecture underlying stature is similar to that in humans, where many genomic regions individually explain only a small amount of phenotypic variance.' );return false" > Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
  • doi:10.1038/s41588-018-0069-0

    Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome' );return false" > Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome
  • doi:10.1038/s41588-018-0052-9

    Identification of AvrStb6, the fungal avirulence effector that triggers Stb6-mediated resistance in wheat, here demonstrates that neither host resistance nor fungicide treatment suppresses fungal sexual reproduction, thus unveiling implications of fungal sex in plant disease control.' );return false" > Stress and sexual reproduction affect the dynamics of the wheat pathogen effector AvrStb6 and strobilurin resistance
  • doi:10.1038/s41588-018-0051-x

    The authors report map-based cloning of the wheat Stb6 gene, which encodes a conserved wall-associated receptor kinase (WAK)-like protein. Stb6 confers gene-for-gene disease resistance to fungal pathogen Zymoseptoria tritici by recognition of a matching pathogen effector.' );return false" > Wheat receptor-kinase-like protein Stb6 controls gene-for-gene resistance to fungal pathogen Zymoseptoria tritici
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