Nature Medicine

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  • doi:10.1038/nm.4493

    The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.' );return false" > H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
  • doi:10.1038/nm.4484

    Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.' );return false" > Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
  • doi:10.1038/nm.4479

    The conserved long noncoding RNA MeXis has anti-atherosclerotic effects in mice by acting with the nuclear hormone receptor LXR in macrophages to promote cholesterol efflux.' );return false" > Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
  • doi:10.1038/nm.4496

    A negative regulator of the Wnt pathway secreted by tumor cells promotes immune evasion by suppressing lymphocyte cytotoxicity.' );return false" > DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation
  • doi:10.1038/nm.4483

    Screening for small-molecule epigenetic modulators identifies HDAC3 inhibitors that promote peripheral myelin repair after nerve injury in rodents.' );return false" > A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration
  • doi:10.1038/nm.4495

    Tailoring treatment to the individual patient has revolutionized cancer therapy, but personalized medicine has yet to make much headway in the treatment of cardiovascular disease. With emerging insight into disease mechanisms and new treatment options, the time is now ripe for the cardiovascular field to adopt a more personalized approach to therapy.' );return false" > Taking personalized medicine to heart
  • doi:10.1038/nm.4486

    A recent study in mice dissects the mechanisms through which muscle damage leads to kidney dysfunction and identifies macrophage extracellular trap (MET) formation as a new pathogenic driver and potential therapeutic target.' );return false" > Macrophages and platelets join forces to release kidney-damaging DNA traps
  • doi:10.1038/nm.4488

    In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells.' );return false" > A new vaccine for tuberculosis in rhesus macaques
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